What is the difference between paper electrophoresis and cellulose acetate electrophoresis?

Cellulose acetate electrophoresis and paper electrophoresis are two different techniques used in the fields of biochemistry and molecular biology to separate and analyze proteins and nucleic acids. Both methods are based on the principle of electrophoresis, which involves the movement of charged particles in an electric field. However, there are several key differences between the two technologies.


Cellulose acetate electrophoresis is a type of zone electrophoresis that uses cellulose acetate strips or sheets as a supporting medium. Cellulose acetate strips are soaked in a buffer solution and placed in an electric field, causing charged molecules to migrate through the medium based on their size and charge. This technology is commonly used for the isolation and analysis of proteins, particularly for clinical diagnostic and research purposes.

Paper electrophoresis, on the other hand, as the name suggests, uses a strip of filter paper as the support medium. The paper strips are dipped in a buffer solution and placed in an electric field to separate the charged molecules. Although paper electrophoresis can also be used to separate proteins and nucleic acids, it is less commonly used in modern laboratories due to its lower resolution and sensitivity compared to other electrophoresis techniques.

One of the main differences between cellulose acetate electrophoresis and paper electrophoresis is the support medium. Cellulose acetate provides a more stable and uniform matrix for molecular separation, resulting in better resolution and reproducibility compared to paper electrophoresis. In addition, cellulose acetate electrophoresis is more suitable for quantitative analysis due to its ability to accurately separate and quantify proteins.

In summary, although cellulose acetate electrophoresis and paper electrophoresis are both based on the principles of electrophoresis, the choice of supporting media and the resulting resolution and sensitivity differ between the two techniques. Cellulose acetate electrophoresis is preferred because of its higher resolution and suitability for quantitative analysis, making it a valuable tool in biochemical and clinical research.


Beijing Liuyi Biotechnology manufactures cellulose acetate membrane  electrophoresis tank for hemoglobin electrophoresis that is the model DYCP-38C cellulose acetate membrane electrophoresis tank, and there are two models of electrophoresis power supply available for the cellulose acetate membrane electrophoresis tank DYY-2C and DYY-6C power supply.

Meanwhile, Beijing Liuyi Biotechnology provides cellulose acetate membrane for customers, and the size of cellulose acetate membrane can be customized. Welcome to ask us for samples and more information.


Beijing Liuyi Biotechnology Co. Ltd (Liuyi Biotechnology) has specialized in manufacturing electrophoresis instruments for more than 50 years with our own professional technical team and R&D center. We have reliable and complete production line from design to inspection, and warehouse, as well as marketing support. Our main products are Electrophoresis Cell (tank/chamber), Electrophoresis Power Supply, Blue LED Transilluminator, UV Transilluminator, Gel Image & Analysis System etc. We also supply the lab instruments like PCR instrument, vortex mixer and centrifuge for laboratory.

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Post time: Apr-10-2024